Table 2 Frequency of IgG subclass deficiency according to the presence or absence of associated hypogammaglobulinemia in the merged cohort (MACRO and STATCOPE cohorts combined)
From: Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD
IgG abnormality | Merged Cohort (n = 1629) |
|---|---|
IgG1 deficiency – no. (%) | 74 (4.5%) |
 With hypogammaglobulinemia – no. (%) | 72 (4.4%) |
 No hypogammaglobulinemia – no. (%) | 2 (0.1%) |
IgG2 deficiency – no. (%) | 93 (5.7%) |
 With hypogammaglobulinemia – no. (%) | 69 (4.2%) |
 No hypogammaglobulinemia – no. (%) | 24 (1.5%) |
IgG3 deficiency – no. (%) | 124 (7.6%) |
 With hypogammaglobulinemia – no. (%) | 72 (4.4%) |
 No hypogammaglobulinemia – no. (%) | 52 (3.2%) |
IgG4 deficiency – no. (%) | 114 (7.0%) |
 With hypogammaglobulinemia – no. (%) | 73 (4.5%) |
 No hypogammaglobulinemia – no. (%) | 41 (2.5%) |
One or more IgG subclass deficiency – no. (%) | 306 (18.8%) |
 With hypogammaglobulinemia – no. (%) | 197 (12.1%) |
 No hypogammaglobulinemia – no. (%) | 109 (6.7%) |
Two IgG subclass deficiencies combined – no. (%) | 47 (2.9%) |
 With hypogammaglobulinemia – no. (%) | 37 (2.3%) |
 No hypogammaglobulinemia – no. (%) | 10 (0.6%) |
Three IgG subclass deficiencies combined – no. (%)a | 20 (1.2%) |
All IgG subclass deficiencies combined – no. (%)a | 4 (0.2%) |