Fig. 3
Effect of OSA-like IH on oxidative stress responses in melanoma lung metastasis mice. qRT-PCR analysis of SOD (A) and p22phox (B) mRNA expression (n = 6 per group) and western blotting analysis of NRF2 protein expression (C a) in tumor tissue from mouse lungs after OSA-like IH exposure and/or tempol treatment (n = 3 per group). The expression level of NRF2 was evaluated by densitometric analysis of western blot bands (C b). All data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01