Table 3 Cytokines and Growth Factors Altered by RT and FG-3019

 Cxcl9

chemokine (C-X-C motif) ligand 9

79.8

4.0

1.1

0.5

 Ccl8

chemokine (C-C motif) ligand 8 (MCP-2)

29.0

2.0

5.4

0.9

 Cxcl10

chemokine (C-X-C motif) ligand 10

17.2

1.5

1.0

0.5

 Ccl1

chemokine (C-C motif) ligand 1

8.9

2.1

2.9

1.2

 Ccl12

chemokine (C-C motif) ligand 12 (MCP-5)

8.3

0.6

1.9

0.7

 Ccl7

chemokine (C-C motif) ligand 7 (MCP-3)

7.9

0.6

1.3

0.5

 Ccl2

chemokine (C-C motif) ligand 2 (MCP-1)

7.3

0.6

1.1

0.5

 Ccl3

chemokine (C-C motif) ligand 3 (MIP-1a)

6.9

0.8

1.3

0.4

 Ccl6

chemokine (C-C motif) ligand 6

5.8

0.7

2.8

1.1

 Ccl9

chemokine (C-C motif) ligand 9 (MIP-1 g)

5.7

0.8

2.2

1.0

 Ccl5

chemokine (C-C motif) ligand 5 (RANTES)

3.9

1.7

0.9

0.8

 Ccl17

chemokine (C-C motif) ligand 17

3.7

1.1

0.9

0.7

 Ccl4

chemokine (C-C motif) ligand 4 (MIP-1 p)

3.6

1.4

0.9

0.6

 Cxcl1

chemokine (C-X-C motif) ligand 1

2.4

0.6

0.7

0.5

 Cxcl16

chemokine (C-X-C motif) ligand 16

2.3

0.7

1.4

0.9

 Cxcl12

chemokine (C-X-C motif) ligand 12 (SDF-1)

2.2

0.5

1.4

1.1

 Cxcl3

chemokine (C-X-C motif) ligand 3 (MIP-2p)

2.0

0.5

2.2

0.7

 Tnfsf18

tumor necrosis factor (ligand) superfamily, member 18

46.8

3.6

2.8

1.0

 Il1rn

interleukin 1 receptor antagonist

5.7

1.2

1.8

0.7

 Il6

interleukin 6

4.7

1.0

1.7

0.6

 Il12b

interleukin 12b

4.7

1.6

0.9

0.8

 Tnfsf8

tumor necrosis factor (ligand) superfamily, member 8

4.4

1.6

1.9

1.1

 C1qtnf9

C1q and tumor necrosis factor related protein 9

3.8

1.7

2.6

1.2

 C1qtnf5

C1q and tumor necrosis factor related protein 5

2.5

1.0

1.7

1.2

 Il18

interleukin 18

2.4

0.6

1.6

1.0

 Il4

interleukin 4

2.4

1.7

0.9

0.7

 Il12a

interleukin 12a

0.5

1.1

0.6

1.4

 Gdf3

growth differentiation factor 3

32.1

3.9

4.2

1.1

 Inhba

inhibin beta-A

7.8

1.1

1.9

1.2

 Gdf6

growth differentiation factor 6 (BMP13)

5.9

0.6

3.7

1.8

 Fst

follistatin

5.7

0.8

1.5

1.1

 Grem1

gremlin 1

4.7

1.8

1.5

0.8

 Gdf15

growth differentiation factor 15

4.0

1.7

3.0

2.6

 Fstl1

follistatin-like 1

4.0

1.0

2.4

1.3

 Ltbp2

latent transforming growth factor beta binding protein 2

3.9

1.0

2.1

1.3

 Ctgf

connective tissue growth factor

3.5

1.1

1.2

0.8

 Bmp8a

bone morphogenetic protein 8a

2.8

1.2

1.9

1.5

 Bmp6

bone morphogenetic protein 6

0.2

0.3

0.4

0.7

 Wnt10a

wingless related MMTV integration site 10a

22.1

1.1

2.3

1.1

 Frzb

frizzled-related protein

8.5

1.2

2.2

0.9

 Sfrp1

secreted frizzled-related protein 1

6.3

0.6

3.2

1.0

 Wisp1

WNT1 inducible signaling pathway protein 1

5.3

0.9

2.4

1.5

 Wisp2

WNT1 inducible signaling pathway protein 2

4.0

0.9

2.7

1.3

 Fzd2

frizzled homolog 2 (Drosophila)

2.8

0.9

1.8

1.2

 Wnt7a

wingless-related MMTV integration site 7A

2.7

1.2

1.3

0.9

 Fzd7

frizzled homolog 7 (Drosophila)

2.0

0.8

1.5

0.8

 Insl6

insulin-like 6

7.9

1.4

3.1

1.2

 Igf1

insulin-like growth factor 1

6.3

0.7

4.7

1.3

 Igfbp2

insulin-like growth factor binding protein 2

3.5

0.8

1.9

1.6

 Igfbp4

insulin-like growth factor binding protein 4

2.6

1.4

1.5

1.1

 Igfbp7

insulin-like growth factor binding protein 7

2.5

0.7

1.5

1.2

 Igfbp6

insulin-like growth factor binding protein 6

0.3

0.6

0.6

0.9

 Retnla

resistin like alpha

10.5

1.7

6.4

1.4

 Angptl7

angiopoietin-like 7

5.0

1.4

1.0

1.0

 Pdgfc

platelet-derived growth factor, C polypeptide

4.2

0.4

1.5

1.0

 Csf3

colony stimulating factor 3 (G-CSF)

3.3

2.3

1.4

1.1

 Angptl3

angiopoietin-like 3

3.2

1.2

1.8

1.3

 Fgf2

fibroblast growth factor 2

2.5

1.3

1.4

0.9

 Pdgfd

platelet-derived growth factor, D polypeptide

2.2

0.9

1.9

1.4

 Pgf

placental growth factor

2.1

0.9

1.1

0.8

 Fgfbp1

fibroblast growth factor binding protein 1

0.4

0.6

0.7

1.1

 Cytl1

cytokine-like 1

0.3

1.0

0.4

0.7

 Retn

resistin

0.2

1.2

0.2

0.3