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Table 1 Proportional representation of cell-type distinguishing genes among RT-elevated genes

From: Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

Cell Type (n, N) Fold Enrichment p
Macrophage (98, 123) 14.2 3E-148
Dendritic Cell (26, 45) 10.3 6E-32
Mesenchymal Cell (28, 73) 6.8 1E-23
Mast Cell (42, 149) 5.0 8E-25
Neutrophil (14, 49) 3.3 2E-05
B Cell (11, 81) 2.4 0.005
Endothelial Cell (9, 43) 2.4 0.012
T Cell (7, 81) 1.5 0.27
Epithelial Cell (Lung) (10, 91) 1.3 0.46
Epithelial Cell (Retina) (2, 115) 0.31 0.08
  1. Enrichment = (n/t)/(N/T), where n = cell-type distinguishing probes in RT-elevated gene set, N = total cell-type distinguishing probes, t = total RT-elevated probes = 1676, and T = total Agilent probes on array platforms from which neutrophil, endothelial or lung epithelial genes were identified (T = 19,515) or from which all other cell-type distinguishing genes were identified (T = 29,806). Observed proportions of cell-type distinguishing genes in the RT-elevated gene set were compared to the proportions expected by chance using the χ2 statistic