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Table 1 Proportional representation of cell-type distinguishing genes among RT-elevated genes

From: Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

Cell Type

(n, N)

Fold Enrichment

p

Macrophage

(98, 123)

14.2

3E-148

Dendritic Cell

(26, 45)

10.3

6E-32

Mesenchymal Cell

(28, 73)

6.8

1E-23

Mast Cell

(42, 149)

5.0

8E-25

Neutrophil

(14, 49)

3.3

2E-05

B Cell

(11, 81)

2.4

0.005

Endothelial Cell

(9, 43)

2.4

0.012

T Cell

(7, 81)

1.5

0.27

Epithelial Cell (Lung)

(10, 91)

1.3

0.46

Epithelial Cell (Retina)

(2, 115)

0.31

0.08

  1. Enrichment = (n/t)/(N/T), where n = cell-type distinguishing probes in RT-elevated gene set, N = total cell-type distinguishing probes, t = total RT-elevated probes = 1676, and T = total Agilent probes on array platforms from which neutrophil, endothelial or lung epithelial genes were identified (T = 19,515) or from which all other cell-type distinguishing genes were identified (T = 29,806). Observed proportions of cell-type distinguishing genes in the RT-elevated gene set were compared to the proportions expected by chance using the χ2 statistic
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Respiratory Research

ISSN: 1465-993X

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