Fig. 5
From: Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab
Cytokine and growth factor cross-talk in late RT-induced lung injury. The mRNAs enriched in response to RT and diminished by pamrevlumab (FG-3019) were used to develop a model of autocrine and paracrine cell-cell communication in RT injured lungs. The RT-induced decrease in endothelial cell-derived BMP6 expression is indicated by blue lettering. The model weights robustness of change, atlas- and literature-based evidence pertaining to proposed cell-type origins and targets, and literature associations with pulmonary fibrosis or other forms of fibrosis