Fig. 3
Smooth muscle contraction and CAS phosphorylation, but not myosin light chain phosphorylation, are regulated by c-Abl. a & b Contractile force was reduced in tissues from c-Ablsmko than in c-Abl-lox mice, which is time- and dose-dependent (n = 5–7). Contractile force is normalized to the force induced by 10−4 M ACh. c Immunoblot analysis was used to assess myosin light chain phosphorylation at Ser-19 of extracts from tracheal rings of c-Abl-lox and c-Ablsmko mice. Data are mean ± SE (n = 4). d ACh-induced CAS phosphorylation at Tyr-410 was reduced in tracheal rings from c-Ablsmko mice as compared to c-Abl-lox mice. Data are mean ± SE (n = 6). **P < 0.01. NS, not significant