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Fig. 5 | Respiratory Research

Fig. 5

From: Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death

Fig. 5

EVLP-directed delivery of MSCs or EVs enhances lung function and inhibits edema in DCD lungs. a-b EVLP with Steen solution significantly increased pulmonary compliance and reduced pulmonary artery (PA) pressure compared to EVLP with Krebs Henseleit (KH) buffer. Supplementation of Steen solution with MSCs or EVs provided enhanced improvement in lung function after EVLP compared to Steen solution alone. c Pulmonary edema was significantly decreased with MSC or EV-treatment during EVLP with Steen solution compared to EVLP with Steen solution alone. d Representative images showing neutrophil immunostaining in lung sections. Neutrophils are stained red and sections are counterstained with hematoxylin. e The number of neutrophils per high power field (HPF) was quantified from immunostained sections. Neutrophil infiltration was significantly attenuated after EVLP with Steen solution compared to KH. Supplementation of Steen solution with MSCs or EVs further decreased neutrophil infiltration compared to Steen solution alone. n = 5–10/group; *, p < 0.05 vs. KH; #p < 0.05 vs. Steen

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Respiratory Research

ISSN: 1465-993X

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