Fig. 3

Cytokine responses measured in bronchoalveolar lavage collected from treated wildtype (WT) (□) and mice not expressing TLR4 (TLR4−/−) (■). Significantly elevated IFN-γ, IL-6 and TNF-α was observed in WT and TLR4−/− mice treated with LPS and AMP-LPS, with these results being greater in WT mice. Only AMP-LPS treated TLR4−/− mice had significantly more TNF-α compared to LPS treated TLR4−/− mice. The amount of these cytokines was not significantly different in AMP treated mice compared to control mice for both strains (* indicates p < 0.05 compared to controls, α = p < 0.05 single treatment compared to all other treatments for the same strain)