Skip to main content

Table 2 Pathways affected in COPD patients compared to smokers with normal lung function

From: Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

  Female Smoker vs COPD Male Smoker vs COPD Joint Smoker vs COPD
Pathways (background No.) Hits p-value pFDRb Hits p-value pFDRb Hits p-value pFDRb
Oxidative phosphorylationa (211) 12 6.0 × 10−6 3.3 × 10−4     3 0.06 0.21
Citrate (TCA) cycle (64) 6 1.1 × 10−4 2.9 × 10−3     3 1.7 × 10−3 0.02
Glutathione metabolism (89) 6 5.7 × 10−4 0.01     1 0.30 0.50
FcγR-mediated phagocytosis (165) 7 2.6 × 10−3 0.03     5 5.0 × 10−4 8.8 × 10−3
Lysosomea (222) 8 5.6 × 10−3 0.04     5 1.3 × 10−3 0.02
Regulation of actin cytoskeleton (387) 11 4.1 × 10−3 0.04     8 1.1 × 10−4 4.5 × 10−3
Phagosome (287) 8 1.5 × 10−2 0.10     5 4.3 × 10−3 0.04
Fatty acid metabolism (94) 4 2.1 × 10−2 0.13 2 7.8 × 10−3 0.29 3 5.4 × 10−3 0.05
Focal adhesion (310)     3 2.7 × 10−2 0.29 5 0.01 0.09
Proteasome        4 3.1 × 10−4 8.2 × 10−3
Endocytosis        7 1.9 × 10−3 0.03
  1. Pathway enrichment analysis for female, male and joint gender comparisons of Smoker vs COPD groups were based on 145, 24 and 116 proteins driving the respective OPLS-DA models,. aThis pathway was detected in female COPD patients by two-dimensional difference gel electrophoresis (2D–DIGE) analysis [15]; More significant pathways were found in female COPD patients for iTRAQ-based proteomics is a platform with higher resolution and more sensitiveness than 2D–DIGE. bFDR corrected p-value by Benjamini and Hochberg’s method; COPDs, smokers with COPD