Table 2 Pathways affected in COPD patients compared to smokers with normal lung function
Female Smoker vs COPD | Male Smoker vs COPD | Joint Smoker vs COPD | |||||||
|---|---|---|---|---|---|---|---|---|---|
Pathways (background No.) | Hits | p-value | pFDRb | Hits | p-value | pFDRb | Hits | p-value | pFDRb |
Oxidative phosphorylationa (211) | 12 | 6.0 × 10−6 | 3.3 × 10−4 | 3 | 0.06 | 0.21 | |||
Citrate (TCA) cycle (64) | 6 | 1.1 × 10−4 | 2.9 × 10−3 | 3 | 1.7 × 10−3 | 0.02 | |||
Glutathione metabolism (89) | 6 | 5.7 × 10−4 | 0.01 | 1 | 0.30 | 0.50 | |||
FcγR-mediated phagocytosis (165) | 7 | 2.6 × 10−3 | 0.03 | 5 | 5.0 × 10−4 | 8.8 × 10−3 | |||
Lysosomea (222) | 8 | 5.6 × 10−3 | 0.04 | 5 | 1.3 × 10−3 | 0.02 | |||
Regulation of actin cytoskeleton (387) | 11 | 4.1 × 10−3 | 0.04 | 8 | 1.1 × 10−4 | 4.5 × 10−3 | |||
Phagosome (287) | 8 | 1.5 × 10−2 | 0.10 | 5 | 4.3 × 10−3 | 0.04 | |||
Fatty acid metabolism (94) | 4 | 2.1 × 10−2 | 0.13 | 2 | 7.8 × 10−3 | 0.29 | 3 | 5.4 × 10−3 | 0.05 |
Focal adhesion (310) | 3 | 2.7 × 10−2 | 0.29 | 5 | 0.01 | 0.09 | |||
Proteasome | 4 | 3.1 × 10−4 | 8.2 × 10−3 | ||||||
Endocytosis | 7 | 1.9 × 10−3 | 0.03 | ||||||