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Fig. 4 | Respiratory Research

Fig. 4

From: Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

Fig. 4

Dysregulation of FcγR-mediated phagocytosis in female COPD patients. The protein levels of ARPC4, ARPC5, ARPC5L, ARPC1B, ARPC2, ARPC3 decreased (blue) and Rac as well as RHOA increased (red) in BAL cells. Rearrangement of the actin cytoskeleton is a necessary driving force for FcγR-mediated phagocytosis [41, 42]. The decreased levels of Arp2/3 and actin cytoskeletal processes may thus imply that FcγR-mediated phagocytosis was hampered in spite of up-regulations of Rac and RhoA in COPD patients. The majority of proteins in the downstream regulation of actin cytoskeleton- and lysosome pathways were down-regulated in female COPD patients (Additional file 2: Table S3) Blue: down-regulated; red: up-regulated. This figure was created with KEGG pathway tool with minor modification

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Respiratory Research

ISSN: 1465-993X

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