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Table 1 Recommendations of step1/2 treatments in different guidelines

From: Corticosteroid plus β2-agonist in a single inhaler as reliever therapy in intermittent and mild asthma: a proof-of-concept systematic review and meta-analysis

Guidelines Step 1 Step 2
GINA [1] Preferred controller choice, none; Preferred controller choice, low dose ICS;
Other controller option, low dose ICS; Other controller option, LTRA, theophylline;
Reliever, as-needed SABA. Reliever, as-needed SABA.
NAEPP [13] Preferred controller choice, none; Preferred controller choice, low dose ICS;
Other controller option, none; Other controller option, cromolyn, LTRA, nedocromil, theophylline;
Reliever, as-needed SABA. Reliever, as-needed SABA.
British Guideline on the Management of Asthma [53] Preferred controller choice, none; Preferred controller choice, low dose ICS;
Other controller option, none; Other controller option, chromones, LTRA, theophylline;
Reliever, as-needed SABA, inhaled ipratropium bromide or theophylline. Reliever, as-needed SABA.
The Chinese guideline for Asthma Management and Prevention [54] Preferred controller choice, none; Preferred controller choice, low dose ICS;
Other controller option, low dose ICS; Other controller option, LTRA, ICS/LABA;
Reliever, as-needed SABA. Reliever, as-needed SABA.
Spanish guideline on the management of asthma [55] Preferred controller choice, none; Preferred controller choice, low dose ICS, LTRA;
Other controller option, none; Other controller option, chromones, theophylline;
Reliever, as-needed SABA, inhaled anticholinergic. Reliever, as-needed SABA.
Japanese guidelines for adult asthma [56] Preferred controller choice, low dose ICS; Preferred controller choice, ICS/LABA;
Other controller option, LTRA, theophylline; Other controller option, low to medium dose ICS, ICS and LTRA, ICS and theophylline;
Reliever, as-needed SABA. Reliever, as-needed SABA.
The Saudi Initiative for Asthma [57] Preferred controller choice, none; Preferred controller choice, low dose ICS;
Other controller option, none; Other controller option, LTRA;
Reliever, as-needed SABA. Reliever, as-needed SABA.
  1. GINA the Global Initiative for Asthma, NAEPP the National Asthma Education and Prevention Program, ICS inhaled corticosteroids, LTRA Leukotriene receptor antagonists, SABA short-acting β2-agonist, ICS/LABA inhaled corticosteroids/long-acting β2-agonist