| FeNO < 25 ppb n = 186 | FeNO ≥ 25 ppb n = 62 | Unadjusted difference (95% CI)a | Adjusted difference (95% CI)a |
---|---|---|---|---|
Lung function | ||||
 FEV1, % pred, mean (SD) | 99.0 (16.5) | 91.2 (17.8) | −7.8 (−12.6, −2.9) | −6.9 (−11.9, −2.0) |
 FVC, % pred, mean (SD) | 108.6 (15.2) | 103.6 (16.0) | −5.0 (−9.4, −0.6) | −4.0 (−8.3, 0.4) |
 FEV1/FVC, mean (SD) | 75.7 (7.6) | 72.4 (8.7) | −3.3 (−5.6, −1.0) | −2.5 (−4.7, −0.2) |
Symptoms | ||||
 Dyspnoea, n (%) | 84 (45) | 30 (48) | 3.2 (−11.3, 17,7) | 6.0 (−8.5, 20.5) |
 Wheezing, n (%) | 66 (36) | 22 (36) | −0.0 (−13.9, 13.9) | 0.6 (−13.5, 14.7) |
 Coughing with mucus, n (%) | 47 (25) | 9 (15) | −10.8 (−21.6, 0.1) | −11.3 (−22.2, −0.4) |
 Coughing without mucus, n (%) | 61 (33) | 17 (27) | −5.4 (−18.5, 7.7) | −4.8 (−17.5, 8.0) |
Symptoms worsen during: | ||||
 Physical activity, n (%) | 95 (51) | 27 (44) | −7.5 (−21.9, 6.9) | −4.5 (−18.9, 10.0) |
 Dust/pollen/animal exposure, n (%) | 48 (26) | 27 (44) | 17.7 (3.8, 31.7) | 16.2 (3.5, 28.8) |
 Foggy weather, n (%) | 68 (37) | 26 (42) | 5.4 (−8.8, 19.6) | 9.0 (−4.4, 22.3) |
 Night, n (%) | 27 (15) | 11 (18) | 3.2 (−7.6, 14.1) | 4.3 (−6.7, 15.2) |
 Getting up in the morning, n (%) | 13 (7) | 4 (7) | 0.5 (−7.7, 6.7) | −1.2 (−8.7, 6.2) |
ICS prescription, n (%) | 93 (50) | 30 (48) | −1.6 (−16.1, 12.9) | 0.2 (−14.7, 15.1) |