Virus-triggered exacerbation in allergic asthmatic children: neutrophilic airway inflammation and alteration of virus sensors characterize a subgroup of patients

Table 2 Asthma control and lung function at steady state, according to the viral status at exacerbation and steady state

	All	V+	V-	V + V+	V + V-	p value (ASD)	p value (ASD)
	n = 66	n = 41	n = 25	n = 17	n = 23	V+ versus V-	V + V+ versus V + V-
Controlled asthma (GINA) (n)	22	14	8	7	7	0.86 (4.6)	0.48 (22.6)
ACT or C-ACT* median [IQR]	22 [20–25]	22 [20–25]	22 [19–25]	23 [21–25]	21 [20–24]	0.58 (13.9)	0.18 (43.8)
Lung function
-FEV1 (% of PV) Pre β2 agonist [IQR]	96 [86–108]	97 [86–109]	96 [85–108]	94 [86–108]	98 [86–110]	0.51 (12.5)	0.79 (7.7)
-FEV1 (% of PV)Post β2 agonist [IQR]	109 [99–117]	108 [97–116]	113 [100–118]	108 [100–115]	108 [95–119]	0.22 (5.7)	0.82 (15.5)
-FEV1/FVC (%)Pre β2 agonist [IQR]	81 [76–86]	82 [77–86]	81 [75–86]	84 [76–89]	79 [77–84]	0.46 (19.5)	0.16 (43.9)
-FEV1/FVC (%) Post β2 agonist [IQR]	88 [83–91]	89 [84–92]	87 [82–89]	90 [86–93]	89 [82–91]	0.23 (0.2)	0.21 (48.2)
-eNO (ppb) [IQR]	17 [10–32]	22 [11–46]	13 [9–22]	22 [13–27]	23 [11–47]	0.06 (51.2)	0.62 (7.8)

V+ identification of a virus (PCR) at exacerbation, V– no identification of a virus at exacerbation, V + V+ identification of a virus at exacerbation and steady state, V + V– identification of a viral infection at exacerbation but not at steady state. Results were expressed as numbers or medians with interquartile range between brackets. ASD absolute standardized difference (%)

ISSN: 1465-993X