Table 2 Overview of studies in experimental rat CDH

Increased expression of ETA (RNA and protein level) and ETB (RNA level)

- Increased expression of ETA and ETB (RNA and protein level) [7]

Increased expression of ECE-1 (RNA level)

- Increased expression of ET-1 after 1 and 6 h of ventilation (RNA level) [18]

- Increased response of arterioles to ET-1 [44]

Increased expression of eNOS (RNA and protein level)

- Increased expression of eNOS (RNA and protein level) [15]

- Increased expression of eNOS after 1 h of ventilation (RNA level) [18]

- Decreased expression of eNOS (RNA and protein level) [13]

Increased expression of Ptgir (RNA level) and decreased expression of Tbxas1 (RNA level)

- Increased levels of prostaglandin I₂ and an increased ratio of prostaglandin I₂ and thromboxane (protein level) [34]