Fig. 5

Functional annotation clustering of target genes of MIR-499 gene family. Enrichment pathway analysis. Heat map showing a) Biological process, (b) Molecular functions and (c) Cellular components for mature forms of both hsa-miR-499a and hsa-miR-499b with p-values <0.05 and microT-CDS threshold 0.5. Degree of color is based on the significant p values of the predicted algorithm by DIANA tools; the red has the highest score of statistical significance. The most pathogenomic feature shown in the heat maps is the involvement of miR-499 in different Toll-like receptor and Fc-epsilon receptor signaling pathways. Subsequent activation of these receptors release cytokines and mediators that drive immediate allergic airway reaction and contribute to intense eosinophil and lymphocyte infiltration in the airways