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Table 1 Demographics of the patients with IPF according to their smoking status

From: Effect of smoking and comorbidities on survival in idiopathic pulmonary fibrosis

  Whole cohort Ex-smoker (ES) Current smoker (CS) Non-smoker (NS) p-value
(between ES and CS)
p-value
(between ES and NS)
N (%)a 132 (100%) 66 (50.0) 17 (12.8) 45 (34.1)   
Pack years (SD) 25.9 (17.66) 23.1 (18.43) 32.9 (13.65)   0.006  
Smoking years (SD) 25.5 (13.54) 21.8 (12.48) 38.1 (8.48)   <0.001  
Male N (%) 97 (73.5) 59 (90.8) 14 (82.4) 20 (44.4) 0.312 <0.001
Age at diagnosis (y)(SD) 70.5 (9.80) 72.4 (7.95) 58.1 (9.93) 71.7 (8.74) <0.001 0.411
Age at death (y) (SD) 74.4 (9.35) 75.8 (8.06) 63.1 (8.13) 76.2 (8.47) <0.001 0.877
Median survival (mo) 45.0 36.0 52.0 55.0 0.029 0.034
Pulmonary function tests (mean (SD))
 FVC% (SD)b 76.7 (18.51) 75.6 (19.51) 76.1 (17.48) 78.3 (17.26) 0.926 0.341
 FEV1% (SD) 77.0 (16.99) 74.9 (17.64) 75.1 (15.77) 80.7 (16.26) 0.866 0.050
 FEV1/FVC% (SD) 101.4 (9.68) 100.0 (9.70) 99.8 (11.84) 103.7 (7.72) 0.995 0.093
 DLco% (SD)c 56.1 (17.51) 53.8 (16.13) 58.9 (19.49) 58.2 (18.98) 0.272 0.139
 CPI (SD) 39.9 (19.96) 41.1 (13.63) 37.9 (14.25) 39.1 (14.67) 0.312 0.341
Radiological diagnoses N (%)
 Definite UIP 79 (61.7) 37 (46.8) 14 (61.7) 28 (35.4) 0.055 0.553
 Possible UIP 28 (21.9) 19 (67.9) 1 (3.6) 8 (28.6) 0.049 0.261
 Not UIP 21 (16.4) 10 (47.6) 2 (11.8) 9 (42.9) 0.723 0.794
  1. Data expressed mean (SD) or N (%) of patients
  2. N number, y years, mo months, FVC forced vital capacity, % pred percent predicted, FEV1 forced expiratory volume in one second, DLco diffusion capacity of carbon monoxide, CPI composite physiologic index, UIP usual interstitial pneumonia, SD standard deviation
  3. asmoking status of 4 patients (2 male and 2 female) was unknown
  4. bSpirometry results from 126 patients
  5. cDiffusion capacity from 124 patients