IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD

Respiratory Research

Table 1 Analytes most significantly associated with IFNγ in COPD sputum samples

Analyte	Median (range)	P′-value	r_s
IFNγ (pg/ml)	5.05 (18–0.45)	-	1
IL-1 receptor antagonist (ng/ml)	202 (16.7–507.3)	2.91E-18	0.72
IL-1α (pg/ml)	225 (17–2290)	1.56E-14	0.66
C-Reactive Protein (ng/ml)	0.035 (0.0132–150)	6.31E-11	0.58
sEGFR (ng/ml)	4.584 (0.385–48.064)	6.87E-11	0.58
α1-Antitrypsin (μg/ml)	11.2 (1.25–140)	1.05E-10	0.58
Haptoglobin (ng/ml)	4.26 (0.0177–62.2)	1.95E-10	0.57
Fibrinogen (ng/ml)	0.905 (0.0569–2.59)	1.98E-10	0.57
IL-1β (pg/ml)	386 (7.39–16,850)	6.57E-10	0.56
IL-18 (pg/ml)	513 (22.1–4550)	1.23E-09	0.55
α2-Macroglobulin (μg/ml)	14.5 (0.915–228)	2.31E-09	0.54

The concentration of 175 analytes was determined in 105 sputum samples collected pre-, during and post-exacerbation of COPD in 24 patients using the human MAPv1.6 (Myriad RBM Inc).The top 11 analytes that had a significant correlation with IFNγ are shown in the table. Correlation was assessed by Spearman rank order correlation (r_s) irrespective of whether stable, exacerbation or convalescence sample. P′-value is the significance value adjusted for multiple testing using Hochberg method to control the family wise error rate to 5%

ISSN: 1465-993X