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Fig. 2 | Respiratory Research

Fig. 2

From: Interactions between glycopyrronium and indacaterol on cholinergic neurotransmission and contractile response in bovine trachealis

Fig. 2

Example of [3H]-ACh-release (a and b panels) and isometric force (c and d panels) in response to electrical stimulation in control (a and c panels) and test (b and d panels) bovine trachealis. DPM are disintegrations per min. S1, S2, and S3 represent first, second, and third electrical stimulation, respectively. Dashed lines represent the extrapolated spontaneous [3H]-ACh-release. The grey areas (A1, A2, and A3) are the [3H]-ACh-release induced by the corresponding stimulations. The electrically-induced [3H]-ACh-release decrease after each stimulation (A1 > A2 > A3) suggesting pre-junctional neuronal depletion of [3H]-ACh. ♦ represent radioactivity measurements of superfusate by liquid scintillation counting. Combination of GLY(○) and IND (×) inhibited the electrically-induced contractile response without altering the [3H]-ACh-release

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Respiratory Research

ISSN: 1465-993X

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