Table 2 Meta-analyzed SNP-by-ETS exposure interactions (additive for effect allele A1) with consistent direction of interaction effects in the three cohorts. Interactions effects for the independent cohorts LifeLines (identification), SAPALDIA (verification) and the Rotterdam Study (verification) are also shown
Meta-analysis | LifeLines | SAPALDIA | Rotterdam Study | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | A1 | Gene (RefSeq) | Bint | SEint | P-value | Direction | I2 | Bint | SEint | P-value | Bint | SEint | P-value | Bint | SEint | P-value |
rs11950494 | G | ACTBL2 (intronic) | −115 | 25 | 4.06E-06 | --- | 0 | −110 | 28 | 7.60E-05 | −162 | 73 | 2.73E-02 | −96 | 88 | 2.75E-01 |
rs2859741 | T | GRIK3 (9.5 kb 5′) | 59 | 13 | 6.78E-06 | +++ | 0 | 69 | 15 | 3.86E-06 | 21 | 31 | 4.86E-01 | 38 | 51 | 4.61E-01 |
rs11153056 | C | PDSS2 (intronic) | 67 | 15 | 7.59E-06 | +++ | 20 | 72 | 16 | 1.36E-05 | 69 | 44 | 1.15E-01 | 1 | 58 | 9.91E-01 |
rs7831729 | C | SNX31 (15 kb 5′) | −76 | 17 | 1.12E-05 | --- | 0 | −80 | 19 | 3.03E-05 | −43 | 49 | 3.88E-01 | −79 | 62 | 1.99E-01 |
rs2084386 | C | PAK2 (intronic) | 90 | 21 | 1.47E-05 | +++ | 7 | 95 | 23 | 2.74E-05 | 28 | 71 | 6.90E-01 | 101 | 74 | 1.74E-01 |
rs9386622 | T | PDSS2 (intronic) | 63 | 15 | 1.67E-05 | +++ | 25 | 65 | 16 | 8.08E-05 | 82 | 43 | 5.55E-02 | 22 | 51 | 6.74E-01 |
rs2090789 | A | LOC100128993 (intronic) | −53 | 13 | 3.95E-05 | --- | 0 | −60 | 15 | 6.54E-05 | −9 | 31 | 7.71E-01 | −99 | 50 | 4.77E-02 |
rs7526579 | C | KCNH1 (intronic) | −67 | 16 | 4.37E-05 | --- | 29 | −75 | 18 | 4.88E-05 | −18 | 44 | 6.79E-01 | −72 | 60 | 2.32E-01 |
rs7030493 | T | TMEM2 (intronic) | −101 | 25 | 4.99E-05 | --- | 0 | −112 | 27 | 3.24E-05 | −42 | 86 | 6.25E-01 | −30 | 98 | 7.59E-01 |