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Table 1 Characteristics of the subjects included from the LifeLines, SAPALDIA and Rotterdam cohort studies

From: Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure

 

LifeLines (identification)

SAPALDIA (replication)

Rotterdam Study 1 (replication)

N with complete data

10,817

1276

1156

ETS exposed (≥1 h/day), n (%)

2473 (23)

296 (23)

219 (19)

FEV1 (ml), mean (sd)

3401 (825)

3153 (864)

2199 (653)

FEV1% of predicteda, mean (sd)

102 (14)

96 (16)

104 (23)

FEV1/FVC (%), mean (sd)

76 (7)

74 (8)

75 (8)

FEV1/FVC < 70%, n (%)

1600 (15)

327 (26)

228 (20)

GOLD2+, n (%)

417 (4)

134 (11)

133 (12)

Use of medication for obstructive airway diseases#, n (%)

676 (6)

164 (18)$

106 (9)

Males, n (%)

4473 (41)

611 (48)

495 (43)

Age, median (min-max)

47 (18–88)

52 (29–72)

78 (72–95)

Ever smokers, n (%)

6266 (58)

703 (55)

771 (67)

Pack years in ever smokers, median (min-max)

10 (0–100)

12 (0–130)

18 (0–145)

  1. ETS environmental tobacco smoke, FEV 1 forced expiratory volume in one second, FVC forced vital capacity
  2. aFEV1 as % of predicted following the reference equations of Quanjer et al. (1993) in LifeLines, [28] and GLI in Rotterdam study
  3. GOLD2+ defined as FEV1/FVC < 70% and FEV1% of predicted <80%
  4. #ATC code R03, $ In SAPALDIA missing data for n = 377