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Table 3 Association of QoL and comorbidities

From: Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry

   EQ-5D VAS WHO-5 SGRQ total UCSD
N (%) mean (SD) Delta 95% CI p value mean (SD) Delta 95% CI p value mean (SD) Delta 95% CI p value mean (SD) Delta 95% CI p value
No comorbidity 151 (20.5%) 65.6 (20.0) (ref) 15.1 (5.6) (ref) 44.1 (22.0) (ref) 55.5 (21.7) (ref)
One comorbid disease 196 (26.6%) 61.5 (20.2) −4.05 (−8.65; 0.56) 0.085 14.5 (6.3) −0.60 (−1.98; 0.78) 0.393 46.1 (21.1) 2.03 (−3.05; 7.11) 0.433 56.0 (21.6) 3.79 (−4.39; 11.96) 0.363
Two comorbid diseases 184 (25.0%) 60.0 (19.1) −5.54 (−10.09; −0.99) 0.017 14.4 (5.5) −0.70 (−2.02; 0.63) 0.305 46.8 (19.4) 2.78 (−2.18; 7.74) 0.271 55.8 (20.7) 9.08 (0.62; 17.54) 0.036
Three comorbid diseases 116 (15.7%) 56.0 (17.9) −9.53 (−14.51; −4.55) <0.001 12.5 (6.1) −2.61 (−4.23; −0.99) 0.002 52.9 (19.5) 8.80 (3.17; 14.44) 0.002 60.9 (21.7) 19.73 (10.59; 28.87)
<0.001
≥Four comorbid diseases 90 (12.2%) 50.9 (18.3) −14.66 (−20.18; −9.14) <0.001 10.6 (6.0) −4.54 (−6.26; −2.82) <0.001 59.1 (16.7) 15.03 (9.40; 20.65) <0.001 61.4 (19.5) 31.36 (20.16; 42.57) <0.001
List of significant comorbidities Left heart insufficiency, Coronary heart disease, Carotid stenosis/ Stroke, Atrial fibrillation, Pulmonary arterial embolism, Pulmonary hypertension, Arterial hypertension, Diabetes mellitus, Emphysema, Lung cancer, Depression, Anxiety Left heart insufficiency, Coronary heart disease, Carotid stenosis/ Stroke, Atrial fibrillation, Pulmonary arterial embolism, Pulmonary hypertension, Arterial hypertension, Diabetes mellitus, Depression, Anxiety Left heart insufficiency, Coronary heart disease, Carotid stenosis/ Stroke, Pulmonary hypertension, Lung cancer, Depression, Anxiety Left heart insufficiency, Coronary heart disease, Carotid stenosis/ Stroke, Pulmonary hypertension, Lung cancer, Depression, Anxiety
  1. 95% CI 95% confidence interval, delta mean difference between the groups, ref. reference group, SD standard deviation