Sirolimus alters lung pathology and viral load following influenza A virus infection

Respiratory Research

Table 2 Respiratory functions on days 4 and 10 post-infection

		Rrs cmH₂O.s/mL	Crs mL/cmH₂O	Rn cmH₂O.s/mL	G cmH₂O/mL	H cmH₂O/mL	FEV _0.05 mL
Day 4	DMSO (n = 3)	0.61 ± 0.10	0.05 ± 0.0	0.27 ± 0.07	3.9 ± 0.5	19.4 ± 1.4	0.87 ± 0.18
	Sirolimus (n = 4)	0.66 ± 0.17	0.04 ± 0.0	0.28 ± 0.17	4.6 ± 1.1	25.0 ± 3.2	0.79 ± 0.08
	IAV (n = 7)	1.44 ± 0.99 ^*	0.03 ± 0.01*	0.40 ± 0.24	9.8 ± 6.1*	36.5 ± 18.3*	0.59 ± 0.41
	Both (n = 4)	0.83 ± 0.13	0.04 ± 0.0	0.28 ± 0.05	5.7 ± 1.2	22.7 ± 2.4	0.48 ± 0.39
Day 10	DMSO (n = 5)	0.56 ± 0.05	0.04 ± 0.00	0.22 ± 0.04	4.2 ± 0.4	20.7 ± 1.6	0.84 ± 0.24
	Sirolimus (n = 5)	0.57 ± 0.06	0.04 ± 0.01	0.18 ± 0.05	4.7 ± 0.6	22.4 ± 5.2	0.95 ± 0.11
	IAV (n = 5)	0.96 ± 0.42*	0.03 ± 0.01	0.35 ± 0.28	6.3 ± 1.5*	30.7 ± 8.3	0.53 ± 0.48
	Both (n = 4)	1.0 ± 0.62	0.03 ± 0.01	0.25 ± 0.02	8.8 ± 6.3	45.0 ± 34.1	0.47 ± 0.53

Rrs, thoracic resistance; Crs, thoracic compliance; Rn, large airway resistance; G, lung tissue damping (resistance); H, lung tissue elastance (stiffness); FEV 0.05, forced expiratory volume at 50 ms
Values are mean ± SD
*designates p < 0.05 compared with DMSO

ISSN: 1465-993X