Fig. 3

Lung histology in infected and uninfected mice. Representative H&E stained lung sections (20×) on days 4, 10 and 25 from 1 of 3 mice per condition are shown (3 separate experiments, see Table 1). Arrows point to areas of patchy interstitial inflammatory infiltrate with alveolar wall thickening. Numbers in parentheses represent score of inflammation. Lung histology in mice treated with sirolimus alone or IAV alone showed a slightly thickened interstitium on day 4 post-infection and peribronchial inflammation (small arrows) on day 10 post-infection. Peribronchial inflammation (large arrow) on day 10 post-infection was more prominent in IAV-infected mice that were administered sirolimus