Skip to main content

Table 4 NGS results, other mutations

From: Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

Gene

 

Mutation

 

COSMIC reference

Pathogenicity prediction

Patient

Allelic frequency

% tum cells

Lung disease

Cancer

MET

Chr7:g.116340214G > A

c.1076G > A

p.Arg359Gln

COSM1286164

probably benign

P01

49.4

50

IPF

SCC

Chr7:g.116411867G > A

c.2942–36G > A

   

P15

 

NS

IPF

ADS

Chr7:g.116411923C > T

c.2962C > T

p.Arg988Cys

COSM1666978

unknown

P05

33.9

30

IPF

SCC

Chr7:g.116411992A > G

c.2977A > G

p.Thr1011Ala

/

unknown

P22

27.6

50

CTD-ILD

ADC

BRAF

Chr7:g.140481402C > G

c.1406G > C

p.Gly469Ala

COSM460

pathogenic

P17

71.8

90

pneumoconiosis

SCC

Chr7:g.140481402C > G

c.1406G > C

p.Gly469Ala

COSM460

pathogenic

P28

46.9

70

drug-induced LF

ADC

Chr7:g.140453134T > C

c.1801A > G

p.Lys601Glu

COSM478

pathogenic

P20

27.6

40

CTD-ILD

ADC

PIK3CA

Chr3:g.178936082G > A

c.1624G > A

p.Glu542Lys

COSM760

pathogenic

P28

64.2

70

drug-induced LF

ADC

Chr3:g.178936082G > A

c.1624G > A

p.Glu542Lys

COSM760

pathogenic

P15

48

NS

IPF

ADS

Chr3.g.178938847A > T

c.2089A > T

p.Met697Leu

/

unknown

P25

8.5

50

NSIP

ADC

FGFR3

Chr4:g.1806149G > C

c.1168G > C

p.Val390Leu

/

unknown

P25

9.6

50

NSIP

ADC

Chr4:g.1807891G > C

c.1950G > C

p.Lys650Asn

COSM3993568

pathogenic

P29

16.3

>50

pneumoconiosis

SmCC

PTEN

Chr10:g.89720729del

c.880del

p.Ser294Valfs*13

/

pathogenic

P02

20.1

40

IPF

SCC

Chr10:g.89720852C > T

c.1003C > T

p.Arg335*

COSM5151

pathogenic

P02

34.5

40

IPF

SCC

STK11

Chr19:g.1221249del

c.772del

p.Asp258Thrfs*29

/

pathogenic

P06

93.6

50

IPF

SCC

Chr19:g.1223125C > G

c.1062C > G

p.Phe354Leu

COSM21360

benign

P20

49.1

40

CTD-ILD

ADC

SMAD4

Chr18:g.48591865C > G

c.1028C > G

p.Ser343*

COSM14111

pathogenic

P05

17.7

30

IPF

SCC

CTNNB1

Chr3:g.41266113C > G

c.110C > G

p.Ser37Cys

COSM5679

pathogenic

P26

34.4

50

NSIP

ADC

DDR2

Chr1:g.162729689T > A

c.775T > A

p.Trp259Arg

/

pathogenic

P24

33.0

70

CTD-ILD

ADS

ERBB4

Chr2:g.212576809C > A

c.1090G > T

p.Gly364Trp

/

pathogenic

P25

18.2

50

NSIP

ADC

FBXW7

Chr4:g.153249370G > A

c.1408C > T

p.His470Tyr

/

probably pathogenic

P06

29.5

50

IPF

SCC

KRAS

Chr12:g.25398285C > A

c.34G > T

p.Gly12Cys

COSM516

pathogenic

P26

35.1

50

NSIP

ADC

EGFR amplification (6.5 copies)

P10

10

IPF

ADC

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us