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Table 4 NGS results, other mutations

From: Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

Gene   Mutation   COSMIC reference Pathogenicity prediction Patient Allelic frequency % tum cells Lung disease Cancer
MET Chr7:g.116340214G > A c.1076G > A p.Arg359Gln COSM1286164 probably benign P01 49.4 50 IPF SCC
Chr7:g.116411867G > A c.2942–36G > A     P15   NS IPF ADS
Chr7:g.116411923C > T c.2962C > T p.Arg988Cys COSM1666978 unknown P05 33.9 30 IPF SCC
Chr7:g.116411992A > G c.2977A > G p.Thr1011Ala / unknown P22 27.6 50 CTD-ILD ADC
BRAF Chr7:g.140481402C > G c.1406G > C p.Gly469Ala COSM460 pathogenic P17 71.8 90 pneumoconiosis SCC
Chr7:g.140481402C > G c.1406G > C p.Gly469Ala COSM460 pathogenic P28 46.9 70 drug-induced LF ADC
Chr7:g.140453134T > C c.1801A > G p.Lys601Glu COSM478 pathogenic P20 27.6 40 CTD-ILD ADC
PIK3CA Chr3:g.178936082G > A c.1624G > A p.Glu542Lys COSM760 pathogenic P28 64.2 70 drug-induced LF ADC
Chr3:g.178936082G > A c.1624G > A p.Glu542Lys COSM760 pathogenic P15 48 NS IPF ADS
Chr3.g.178938847A > T c.2089A > T p.Met697Leu / unknown P25 8.5 50 NSIP ADC
FGFR3 Chr4:g.1806149G > C c.1168G > C p.Val390Leu / unknown P25 9.6 50 NSIP ADC
Chr4:g.1807891G > C c.1950G > C p.Lys650Asn COSM3993568 pathogenic P29 16.3 >50 pneumoconiosis SmCC
PTEN Chr10:g.89720729del c.880del p.Ser294Valfs*13 / pathogenic P02 20.1 40 IPF SCC
Chr10:g.89720852C > T c.1003C > T p.Arg335* COSM5151 pathogenic P02 34.5 40 IPF SCC
STK11 Chr19:g.1221249del c.772del p.Asp258Thrfs*29 / pathogenic P06 93.6 50 IPF SCC
Chr19:g.1223125C > G c.1062C > G p.Phe354Leu COSM21360 benign P20 49.1 40 CTD-ILD ADC
SMAD4 Chr18:g.48591865C > G c.1028C > G p.Ser343* COSM14111 pathogenic P05 17.7 30 IPF SCC
CTNNB1 Chr3:g.41266113C > G c.110C > G p.Ser37Cys COSM5679 pathogenic P26 34.4 50 NSIP ADC
DDR2 Chr1:g.162729689T > A c.775T > A p.Trp259Arg / pathogenic P24 33.0 70 CTD-ILD ADS
ERBB4 Chr2:g.212576809C > A c.1090G > T p.Gly364Trp / pathogenic P25 18.2 50 NSIP ADC
FBXW7 Chr4:g.153249370G > A c.1408C > T p.His470Tyr / probably pathogenic P06 29.5 50 IPF SCC
KRAS Chr12:g.25398285C > A c.34G > T p.Gly12Cys COSM516 pathogenic P26 35.1 50 NSIP ADC
EGFR amplification (6.5 copies) P10 10 IPF ADC