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Table 3 NGS results, TP53 mutations

From: Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

Gene   Mutation   COSMIC reference Pathogenicity prediction Patient Allelic frequency % tum cells Lung disease Cancer
TP53 Chr17:g.7579383T > G c.304A > C p.Thr102Pro / benign P09 11.0 NS IPF ADC
Chr17:g.7578461C > A c.469G > T p.Val157Phe COSM10670 pathogenic P18 54.0 70 CTD-ILD SCC
Chr17:g.7578457C > A c.473G > T p.Arg158Leu COSM10714 pathogenic P20 27.8 40 CTD-ILD ADC
Chr17:g.7578454G > A c.476C > T p.Ala159Val COSM11148 pathogenic P15 44 NS IPF ADS
Chr17:g.7578406C > T c.524G > A p.Arg175His COSM10648 pathogenic P21 42.2 70 CTD-ILD ADC
Chr17:g.7578388C > G c.542G > C p.Arg181Pro COSM45046 pathogenic P09 22.1 NS IPF ADC
Chr17:g.7578272G > T c.577C > A p.His193Asn COSM43935 pathogenic P03-ADC 59.3 70 IPF ADC
Chr17:g.7578272G > A c.577C > T p.His193Tyr COSM10672 pathogenic P01 22.4 50 IPF SCC
Chr17:g.7577574T > C c.707A > G p.Tyr236Cys COSM10731 pathogenic P30 84.0 70 IPF SmCC
Chr17:g.7577559G > A c.722C > T p.Ser241Phe COSM10812 pathogenic P27 16.4 20 pneumoconiosis ADC
Chr17:g.7577559G > A c.722C > T p.Ser241Phe COSM10812 pathogenic P29 84.7 >50 pneumoconiosis SmCC
Chr17:g.7577539G > A c.742C > T p.Arg248Trp COSM10656 pathogenic P11 42.8 70 IPF ADC
Chr17:g.7577535C > A c.746G > T p.Arg249Met COSM43871 pathogenic P08 28.9 40 IPF SCC
Chr17:g.7577535C > A c.746G > T p.Arg249Met COSM43871 pathogenic P24 61.0 70 CTD-ILD ADS
Chr17:g.7577120C > A c.818G > T p.Arg273Leu COSM10779 pathogenic P16 68.1 40 IPF LCNEC
Chr17:g.7577115dup c.823dup p.Cys275Leufs*31 / pathogenic P04 16.2 25 IPF SCC
Chr17:g.7577108C > A c.830G > T p.Cys277Phe COSM10749 pathogenic P02 42.5 40 IPF SCC
Chr17:g.7577096_7577099del c.839_842del p.Arg280Thrfs*64 / pathogenic P05 63.6 30 IPF SCC
Chr17:g.7577046C > A c.892G > T p.Glu298* COSM10710 pathogenic P19 65.1 40 pneumoconiosis SCC
Chr17:g.7573976T > A c.1051A > T p.Lys351* COSM1522202 pathogenic P17 61.1 90 pneumoconiosis SCC
  1. ADC adenocarcinoma, ADS adenosquamous carcinoma, CTD-ILD connective tissue disease associated-interstitial lung disease, IPF idiopathic pulmonary fibrosis, LCNEC large cell neuro-endocrine carcinoma, NSIP non-specific interstitial pneumonia, SCC squamous cell carcinoma, SmCC small cell carcinoma