Patient

Cancer type

Cancer differenciation

Diagnostic immunohistochemistry (IHC)

Therapeutic IHC


TTF1

p40/p63

others

ALK

ROS1

PDL1


Idiopathic pulmonary fibrosis

P1

SCC

keratinizing

/

/
 
/

/

/

P2

SCC

nonkeratinizing

TTF1

p40+
 
/

/

/

P3

SCC

basaloid,

/

p63+

CK7

/

/

<1%

keratinizing

P4

SCC

keratinizing

TTF1

p40+
 
/

/

5%

P5

SCC

nonkeratinizing

TTF1

p63+

NapsinA CK5/6+

/

/

/

P6

SCC

keratinizing

TTF1

p63+
 
/

/

/

P7

SCC

keratinizing

TTF1

p40+
 
/

/

10%

P8

SCC

nonkeratinizing

TTF1

p40+
 
/

/

0%

P9

ADC

acinar

TTF1+
 
CK7+

neg

/

/

P10

ADC

acinar

TTF1

p63
 
/

/

/

P3

ADC

solid

TTF1+

p63
 
neg

neg

<1%

P11

ADC

NS

TTF1

p63

NapsinA+

/

/

/

P12

ADC

mucinous

TTF1

/

CK7+ CK20+

neg

/

/

P13

ADC

acinar

TTF1+

p40

CK7+ CD56

neg

neg

1%

P14

ADS

acinar

TTF1

p40+

CK7+

neg

neg

20%

P15

ADS

papillary

TTF1+

p40+
 
neg

neg

15%

P16

LCNEC

/

TTF1

/

chromoA+ CD56+

/

/

/

synapto + CK5/6

P30

SmCC

/

TTF1+

/

chromoA+ CD56+

/

/

/

synapto+

Connective Tissue DiseaseInterstitial Lung Disease

P18

SCC

keratinizing

TTF1

p40+
 
/

/

40%

P20

ADC

papillary

TTF1+

/
 
neg

neg

<1%

P21

ADC

solid

TTF1+

p40
 
neg

neg

70%

P24

ADS

solid

TTF1+

p40+
 
neg

neg

10%

P23

ADC

solid

TTF1+

p63

NapsinA+

/

/

/

P22

ADC

acinar

TTF1+

/

CK7+

neg

neg

0%

Nonspecific interstitial pneumonia

P25

ADC

acinar

TTF1+

p40+
 
neg

neg

<1%

P26

ADC

papillary

TTF1+

/
 
neg

neg

1%

Pneumoconiosis

P17

SCC

keratinizing

TTF1

p40+
 
/

/

1%

P27

ADC

solid

TTF1+

p40+
 
/

/

/

P19

SCC

nonkeratinizing

TTF1

p63+

CK5/6+

/

/

/

P29

SmCC

/

TTF1

/

CD56+

/

/

/

Druginduced lung fibrosis

P28

ADC

acinar

TTF1+

/

NapsinA+

/

/

/


ADC adenocarcinoma, ADS adenosquamous carcinoma, LCNEC large cell neuroendocrine carcinoma, SCC squamous cell carcinoma, SmCC small cell carcinoma