Table 2 Pathological features
Patient | Cancer type | Cancer differenciation | Diagnostic immunohistochemistry (IHC) | Therapeutic IHC | ||||
|---|---|---|---|---|---|---|---|---|
TTF1 | p40/p63 | others | ALK | ROS1 | PDL1 | |||
Idiopathic pulmonary fibrosis | ||||||||
P1 | SCC | keratinizing | / | / | / | / | / | |
P2 | SCC | nonkeratinizing | TTF1- | p40+ | / | / | / | |
P3 | SCC | basaloid, | / | p63+ | CK7- | / | / | <1% |
keratinizing | ||||||||
P4 | SCC | keratinizing | TTF1- | p40+ | / | / | 5% | |
P5 | SCC | nonkeratinizing | TTF1- | p63+ | NapsinA- CK5/6+ | / | / | / |
P6 | SCC | keratinizing | TTF1- | p63+ | / | / | / | |
P7 | SCC | keratinizing | TTF1- | p40+ | / | / | 10% | |
P8 | SCC | nonkeratinizing | TTF1- | p40+ | / | / | 0% | |
P9 | ADC | acinar | TTF1+ | CK7+ | neg | / | / | |
P10 | ADC | acinar | TTF1- | p63- | / | / | / | |
P3 | ADC | solid | TTF1+ | p63- | neg | neg | <1% | |
P11 | ADC | NS | TTF1- | p63- | NapsinA+ | / | / | / |
P12 | ADC | mucinous | TTF1- | / | CK7+ CK20+ | neg | / | / |
P13 | ADC | acinar | TTF1+ | p40- | CK7+ CD56- | neg | neg | 1% |
P14 | ADS | acinar | TTF1- | p40+ | CK7+ | neg | neg | 20% |
P15 | ADS | papillary | TTF1+ | p40+ | neg | neg | 15% | |
P16 | LCNEC | / | TTF1- | / | chromoA+ CD56+ | / | / | / |
synapto + CK5/6- | ||||||||
P30 | SmCC | / | TTF1+ | / | chromoA+ CD56+ | / | / | / |
synapto+ | ||||||||
Connective Tissue Disease-Interstitial Lung Disease | ||||||||
P18 | SCC | keratinizing | TTF1- | p40+ | / | / | 40% | |
P20 | ADC | papillary | TTF1+ | / | neg | neg | <1% | |
P21 | ADC | solid | TTF1+ | p40- | neg | neg | 70% | |
P24 | ADS | solid | TTF1+ | p40+ | neg | neg | 10% | |
P23 | ADC | solid | TTF1+ | p63- | NapsinA+ | / | / | / |
P22 | ADC | acinar | TTF1+ | / | CK7+ | neg | neg | 0% |
Non-specific interstitial pneumonia | ||||||||
P25 | ADC | acinar | TTF1+ | p40+ | neg | neg | <1% | |
P26 | ADC | papillary | TTF1+ | / | neg | neg | 1% | |
Pneumoconiosis | ||||||||
P17 | SCC | keratinizing | TTF1- | p40+ | / | / | 1% | |
P27 | ADC | solid | TTF1+ | p40+ | / | / | / | |
P19 | SCC | nonkeratinizing | TTF1- | p63+ | CK5/6+ | / | / | / |
P29 | SmCC | / | TTF1- | / | CD56+ | / | / | / |
Drug-induced lung fibrosis | ||||||||
P28 | ADC | acinar | TTF1+ | / | NapsinA+ | / | / | / |