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Table 2 Pathological features

From: Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses

Patient Cancer type Cancer differenciation Diagnostic immunohistochemistry (IHC) Therapeutic IHC
TTF1 p40/p63 others ALK ROS1 PDL1
Idiopathic pulmonary fibrosis
 P1 SCC keratinizing / /   / / /
 P2 SCC nonkeratinizing TTF1- p40+   / / /
 P3 SCC basaloid, / p63+ CK7- / / <1%
keratinizing
 P4 SCC keratinizing TTF1- p40+   / / 5%
 P5 SCC nonkeratinizing TTF1- p63+ NapsinA- CK5/6+ / / /
 P6 SCC keratinizing TTF1- p63+   / / /
 P7 SCC keratinizing TTF1- p40+   / / 10%
 P8 SCC nonkeratinizing TTF1- p40+   / / 0%
 P9 ADC acinar TTF1+   CK7+ neg / /
 P10 ADC acinar TTF1- p63-   / / /
 P3 ADC solid TTF1+ p63-   neg neg <1%
 P11 ADC NS TTF1- p63- NapsinA+ / / /
 P12 ADC mucinous TTF1- / CK7+ CK20+ neg / /
 P13 ADC acinar TTF1+ p40- CK7+ CD56- neg neg 1%
 P14 ADS acinar TTF1- p40+ CK7+ neg neg 20%
 P15 ADS papillary TTF1+ p40+   neg neg 15%
 P16 LCNEC / TTF1- / chromoA+ CD56+ / / /
synapto + CK5/6-
 P30 SmCC / TTF1+ / chromoA+ CD56+ / / /
synapto+
Connective Tissue Disease-Interstitial Lung Disease
 P18 SCC keratinizing TTF1- p40+   / / 40%
 P20 ADC papillary TTF1+ /   neg neg <1%
 P21 ADC solid TTF1+ p40-   neg neg 70%
 P24 ADS solid TTF1+ p40+   neg neg 10%
 P23 ADC solid TTF1+ p63- NapsinA+ / / /
 P22 ADC acinar TTF1+ / CK7+ neg neg 0%
Non-specific interstitial pneumonia
 P25 ADC acinar TTF1+ p40+   neg neg <1%
 P26 ADC papillary TTF1+ /   neg neg 1%
Pneumoconiosis
 P17 SCC keratinizing TTF1- p40+   / / 1%
 P27 ADC solid TTF1+ p40+   / / /
 P19 SCC nonkeratinizing TTF1- p63+ CK5/6+ / / /
 P29 SmCC / TTF1- / CD56+ / / /
Drug-induced lung fibrosis
 P28 ADC acinar TTF1+ / NapsinA+ / / /
  1. ADC adenocarcinoma, ADS adenosquamous carcinoma, LCNEC large cell neuro-endocrine carcinoma, SCC squamous cell carcinoma, SmCC small cell carcinoma