Table 1 Hemodynamics and echocardiography data at 28 day after MCT injection

No. of surviving rats

15

18

16

15

Body weight, g

458 ± 8

390 ± 6*

436 ± 7*^,†

428 ± 7*^,†

Heart Rate, bpm

432 ± 9

446 ± 15

440 ± 10

437 ± 17

LV Cardiac Output (ml/min)

145 ± 3

105 ± 4*

107 ± 4*

116 ± 3.4*

RV Ejection Fraction (%)

68.3 ± 3.6

48.2 ± 4.4*

65.6 ± 4.2^†

62.5 ± 5.1^†

Pulmonary artery acceleration time, ms

34.2 ± 1

25.8 ± 1.4*

33 ± 0.9†

30.6 ± 0.7^†

Pulmonary artery, cm

0.32 ± 0.01

0.43 ± 0.04*

0.34 ± 0.02^†

0.35 ± 0.03^†

Mean blood pressure

97.3 ± 4.2

90.5 ± 3.8

92.3 ± 2.2

89.4 ± 3.3

RV/BW (mg/g)

3.8 ± 0.2

12 ± 1*

6.2 ± 0.8*^,†

7.1 ± 0.9*^,†

RV wall thickness, cm

0.14 ± 0.02

0.23 ± 0.03*

0.16 ± 0.04^†

0.18 ± 0.02^†

RV area, mm²

12.6 ± 0.4

26 ± 0.8*

14.2 ± 0.5^†

15.6 ± 0.4^†

LV area, mm²

23.8 ± 0.4

24.6 ± 0.6

24.3 ± 0.7

25.8 ± 0.4