Fig. 6
From: Role of P2X7R in the development and progression of pulmonary hypertension
Measurement of right ventricular systolic pressure (using a Millar catheter) shows a reduction in the RVSP in PH rats following pretreatment and treatment of the animals with A-740003 (a, c). A-740003 also reduced the RV/LV + S ratio in the MCT-treated rats (b). The representative visual shape of the RV is also presented (d). Kaplan-Meier survival curves show that A-740003-treated rats had a non-significantly higher survival rate than those in the vehicle group (e). The data are presented as the mean ± SD. n = 15–18. **p < 0.01 compared with the sham group; †p < 0.05 compared with the P/MCT vehicle group. RVSP, right ventricle systolic pressure; RV/LV + S ratio, weight ratio of the right ventricle to the left ventricle plus the septum