Fig. 9

Inhibition of the p38 MAPK pathway significantly inhibits the induction of fibronectin by each HRV seroptype alone and in combination with TGF-β₁. BEAS-2B cells were pre-treated for 1 h with the p38 MAPK pathway inhibitor, SB203580 (SB), and then stimulated with medium, HRV-16, HRV-1A, TGF-β₁, HRV-16 + TGF-β₁, or HRV-1A + TGF-β₁ for 24 h. a Representative western blot for fibronectin using HRV-16 with and without SB. b Densitometry analysis for fibronectin using HRV-16 with and without SB. (n = 6). c Representative western blot for fibronectin using HRV-1A with and without SB. d Densitometry analysis for fibronectin using HRV-1A with and without SB. (n = 6). Asterisk indicates significance for comparisons shown by Dunn’s post-hoc analysis after Kruskal-Wallis ANOVA