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Table 4 Sensitivity of tumour markers according to tumour type

From: Evaluation of two strategies for the interpretation of tumour markers in pleural effusions

 

Single cut-offa

Ratio F/Sb

Tumour type

CA15-3

CEA

CA19-9

CA72-4

All TM

CA15-3

CEA

CA19-9

CA72-4

All TM

Lung cancer (n = 46)

43.5% (20/46)

43.5% (20/46)

28.3% (13/46)

30.4% (14/46)

71.7% (33/46)

36.9% (17/46)

78.2% (36/46)

41.3% (19/46)

39.1% (18/46)

89.1% (41/46)

CUP (n = 18)

50.0% (9/18)

72.2% (13/18)

33.3% (6/18)

55,5% (10/18)

94.4% (17/18)

55.5% (10/18)

72.2% (13/18)

50.0% (9/18)

55.5% (10/18)

88.9% (16/18)

Mesothelioma (n = 15)

6.7% (1/15)

0.0% (0/15)

0.0% (0/15)

0.0% (0/15)

6.7% (1/15)

46.7% (7/15)

0.0% (0/15)

6.7% (1/15)

0.0% (0/15)

46.7% (7/15)

Breast cancer (n = 13)

61.5% (8/13)

7.7% (1/13)

0.0% (0/13)

38.5% (5/13)

92.3% (12/13)

53.8% (7/13)

61.5% (8/13)

0% (0/13)

38.5% (5/13)

84.6% (11/13)

Lymphoma (n = 9)

0.0% (0/9)

0.0% (0/9)

0.0% (0/9)

0.0% (0/9)

0.0% (0/9)

0% (0/9)

0% (0/9)

0% (0/9)

0% (0/9)

0% (0/9)

Bladder cancer (n = 5)

100% (5/5)

60.0% (3/5)

0.0% (0/5)

40.0% (2/5)

100% (5/5)

60.0% (3/5)

80.0% (4/5)

40.0% (2/5)

40.0% (2/5)

100% (5/5)

Ovarian cancer /PSPC* (n = 3)

66.6% (2/3)

33.3% (1/3)

33.3% (1/3)

66.6% (2/3)

100% (3/3)

66.6% (2/3)

33.3% (1/3)

33.3% (1/3)

66.6% (2/3)

100% (3/3)

Stomach cancer (n = 3)

33.3% (1/3)

100% (3/3)

100% (3/3)

100% (3/3)

100% (3/3)

33.3% (1/3)

66.6% (2/3)

66.6% (2/3)

100% (3/3)

100% (3/3)

Cholangiocarcinoma (n = 2)

0.0% (0/2)

50% (1/2)

50% (1/2)

0.0% (0/2)

50% (1/2)

0% (0/2)

50.0% (1/2)

50.0% (1/2)

0.0% (0/2)

50.0% (1/2)

Colon cancer (n = 2)

0.0% (0/2)

50% (1/2)

50.0% (1/2)

50% (1/2)

50% (1/2)

50.0% (1/2)

50.0% (1/2)

0.0% (0/2)

50.0% (1/2)

50.0% (1/2)

  1. aCut-off CEA 60 μg/L; CA15-3 80 KU/L; CA72-421 KU/L; CA19-9 201 KU/L
  2. bF/S > 1.2 and at least one of these CEA > 5 μg/L, CA15-3 > 30 KU/L, CA72-4 > 6.9 KU/L and CA19-9 > 37 KU/L
  3. PSPC Papillary serous of peritoneum carcinoma, CUP Cancer of unknown primar