Table 1 Patient data for life-years gained analysis
Subject | Treatment Arm | Last AE term | Reason for discharge | Age at randomization | Sex | Baseline FEV1 % predicted | Baseline lung density (g/L) | Last measured lung density (g/L) | Time from the study start date to last measured lung density (years) |
|---|---|---|---|---|---|---|---|---|---|
RAPID-RCT | |||||||||
1 | Placebo | Chest infection | Lung transplantation | 57 | M | 44.9 | 6.5 | 3.5 | 0.40 |
2 | A1-PI | Dyspnea | Withdrawal by patient | 50 | F | 26.7 | 14.3 | 12.5 | 1.11 |
3 | Placebo | Pulmonary infiltration | Withdrawal by patient | 56 | M | 34.5 | 31.3 | 29.4 | 1.11 |
4 | A1-PI | Severe respiratory insufficiency | Death | 58 | F | 35.3 | 25.1 | 25.1 | 0.00 |
5 | A1-PI | UTI | Lung transplantation | 55 | M | 62.6 | 22.8 | 24.3 | 0.25 |
RAPID-OLE | |||||||||
6 | A1-PI (Early-Start) | Cross reactivity to birch allergy | Death | 56 | M | 40.2 | 35.1 | 25.7 | 2.99 |
7 | A1-PI (Delayed-Start) | Mycobacteria infection | Lung transplantation | 48 | F | 33.0 | 32.7 | 23.2 | 3.94 |