Blood and sputum eosinophils in COPD; relationship with bacterial load

Kolsum, Umme; Donaldson, Gavin C.; Singh, Richa; Barker, Bethan L.; Gupta, Vandana; George, Leena; Webb, Adam J.; Thurston, Sarah; Brookes, Anthony J; McHugh, Timothy D.; Wedzicha, Jadwiga A.; Brightling, Christopher E.; Singh, Dave

doi:10.1186/s12931-017-0570-5

Respiratory Research

Table 4 Comparison of blood and sputum counts between baseline and exacerbation for PPM positive and PPM negative groups

From: Blood and sputum eosinophils in COPD; relationship with bacterial load

BLOOD	PPM positive n = 78			PPM negative n = 31
BLOOD	Baseline	Exacerbation	p value	Baseline	Exacerbation	p value
White blood cell count (x10⁹/L)	7.4 [4.4–15.6]	8.9 [2.8–20.5]	<0.0001	7.00 [5.03–13.4]	8.90 [4.90–15.40]	<0.0001
Neutrophil count (x10⁹/L)	4.95 [2.95–12.23]	6.13 [1.42–18.12]	<0.0001	4.38 [2.97–8.29]	5.50 [2.36–10.98]	0.004
Eosinophil blood count (x10⁹/L)	0.23 [0.05–0.90]	0.17 [0.00–0.76]	0.008	0.22 [0.04–0.57]	0.23 [0.02–0.78]	0.08
Lymphocyte blood count (x10⁹/L)	1.70 [0.75–3.67]	1.89 [0.44–4.66]	0.13	1.67 [1.00–4.25]	1.79 [0.50–3.03]	0.69
Monocyte blood count (x10⁹/L)	0.55 [0.28–1.41]	0.68 [0.26–1.87]	<0.0001	0.6 [0.4–1.06]	0.77 [0.42–1.43]	<0.0001
SPUTUM	PPM positive n = 22			PPM negative n = 8
SPUTUM	Baseline	Exacerbation	p value	Baseline	Exacerbation	p value
Total Cell count (x10⁶/g)	5.84 [0.63–84.56]	10.58 [0.41–154.5]	0.14	3.01 [0.25–5.27]	6.51 [0.60–36.67]	0.008
Sputum Neutrophil count (x10⁶/g)	5.14 [0.02–82.44]	9.79 [0.08–151.6]	0.11	0.73 [0.16–3.61]	5.19 [0.19–35.75]	0.05
Sputum Macrophage count (x10⁶/g)	0.74 [0.14–4.22]	0.11 [0.00–1.55]	<0.0001	0.74 [0.04–2.16]	0.07 [0.01–0.37]	0.02
Sputum Eosinophil count (x10⁶/g)	0.07 [0.00–0.52]	0.01 [0.00–0.31]	0.09	0.02 [0.01–0.50]	0.03 [0.00–3.17]	0.61
Sputum Lymphocyte count (x10⁶/g)	0.00 [0.00–0.25]	0.00 [0.00–0.27]	0.11	0.00 [0.00–0.01]	0.005 [0.00–0.09]	0.31
Sputum Epithelial count (x10⁶/g)	0.19 [0.00–2.32]	0.16 [0.00–0.84]	0.56	0.20 [0.04–0.30]	0.24 [0.03–0.95]	0.74
Sputum Neutrophil %	84.00 [3.00–97.75]	90.75 [19.00–99.25]	0.21	55.38 [7.00–83.53]	78.00 [5.25–97.5]	0.11
Sputum Macrophage %	11.12 [1.50–88.50]	6.00 [0.50–70.25]	0.28	26.88 [8.82–85.5]	9.00 [1.5–35.5]	0.02
Sputum Eosinophil %	0.75 [0.00–6.98]	0.23 [0.00–2.00]	0.046	1.88 [0.29–12.75]	1.00 [0.00–86.5]	0.38
Sputum Lymphocyte %	0.00 [0.00–0.25]	0.00 [0.00–1.00]	0.35	0.00 [0.00–2.50]	0.13 [0.00–0.25]	0.63
Sputum Epithelial cell %	2.13 [0.00–40.00]	2.13 [0.00–54.76]	0.89	7.68 [1.50–17.50]	5.00 [0.75–11.00]	0.25

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