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Table 3 Logistic regression models assessing associations between SUMF1 SNPs and COPD (additive model) in the LifeLines cohort

From: Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease

   

LifeLines cohort

n = 1483

SUMF1 SNP

Ref

Var

OR

SE

p-value

rs793391

A

C

1.42

0.13

0.0066

rs308739

A

C

0.40

0.36

0.010

rs807785

C

T

0.82

0.13

0.14

rs1688411

T

G

0.77

0.18

0.16

rs1968930

A

C

0.78

0.19

0.19

rs1687863

G

A

0.84

0.15

0.24

rs17030493

T

C

0.87

0.17

0.39

rs1688413

C

T

0.90

0.14

0.44

rs809437

A

G

0.92

0.13

0.55

rs17040589

C

T

0.88

0.25

0.62

rs11915920

C

T

0.99

0.12

0.90

rs2819562

C

T

1.01

0.12

0.96

  1. Shown are SNPs that were significant eQTLs and overlapped with the array used to genotype the Lifelines cohort. OR = odds ratio, SE = standard error, p-value is from logistic regression models assessing associations between SNPs (additive model) and COPD, adjusted for sex, age, and pack years. Smoking controls were defined as an FEV1/FVC > 0.7 and COPD was defined as an FEV1/FVC < 0.7. Ref = reference allele. Var = variance allele. Bold indicates significant values
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Respiratory Research

ISSN: 1465-993X

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