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Table 2 Effect of Thapsigargin and HDAC Inhibitors on GRP78 Secretion (Mean ± SE, n = 5–7 expts.)

From: Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers

Treatment

Medium GRP78

Lysate GRP78

Medium/Lysate

% Control

% Control

% Control

HDAC Inhibitors

199 ± 22++

97 ± 8

203 ± 22++

Thapsigargin

357 ± 102*

139 ± 10+

280 ± 94*

  1. Human airway epithelial cells (HAEC) were treated with thapsigargin (TG, 1 μM); HDAC inhibitors (vorinostat + MS275 + trichostatin A, all 2 μM); or vehicle control (DMSO 0.2% and ethanol 0.1%) for 24 h. * p = 0.03; + p = 0.01; ++ p = 0.006
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Respiratory Research

ISSN: 1465-993X

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