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Fig. 8 | Respiratory Research

Fig. 8

From: Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

Fig. 8

Effect of acute injury with H1N1 influenza infection on WT and Aldh2 −/− mice. WT (n = 8) and Aldh2 −/− (n = 7) mice were inoculated with H1N1 virus and observed for 8 days. Representative H&E images from H1N1-infected mouse lungs showing extensive inflammatory cell infiltration and pneumonia in both WT (a) and Aldh2 −/− (b) lungs. Representative immune fluorescence stained images showing areas of damaged epithelial cells in the lung parenchyma in WT (c) and Aldh2 −/− (d) lungs. (note the presence of few alveolar type II cells, (SPC-green)). The damage is also observed in the airway lining (note the reduced nuclear density, fewer club cells (CC10-red), and short ciliated cells (β-tubulin-cyan)) in WT (e) and Aldh2 −/− (f). Viral load comparison between WT (g) and Aldh2 −/− (h) mice by staining for hemagglutinin (HA-green), showed no difference. Scale bars: 50 μm. Nuclei were stained with DAPI (blue) (c-h)

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