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Table 2 Associations between residential measures of PM2.5, V and Day 6 DNA methylation in adjusted models (N:n = 146:229)

From: Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children

  

RRadj a [95% CI]

Gene

CpG sites

PM2.5

V

IL4

−326

1.16 [0.84–1.61]

0.80 [0.65–0.98]*

 

−48

1.04 [0.76–1.43]

1.05 [0.83–1.34]

IFNγ

−186

0.87 [0.64–1.19]

1.23 [0.96–1.58]

 

−54

1.03 [0.79–1.35]

0.81 [0.67–0.98]*

NOS2A

+5099

1.07 [0.79–1.45]

0.97 [0.80–1.19]

 

+5106

1.07 [0.74–1.54]

0.98 [0.78–1.23]

ARG2

−32, −30, and −26b

1.07 [0.97–1.17]

0.96 [0.89–1.02]

  1. N: number of repeat subjects included for the analysis and n: number of observations from both Time 1 and Time 2
  2. aAdjusted for race/ethnicity, sex, age, heating season, asthma diagnosis, overweight, and DNA methylation at Day 0 (Two-pollutant models)
  3. bAverage of ARG2 CpG sites of −32, −30, and −26
  4. * p-value < 0.05
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Respiratory Research

ISSN: 1465-993X

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