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Table 1 Diagnostic relevance of CD44 in MPM

From: CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives

Function Method/specimen Reference
High CD44 level indicates presence of neoplastic cells IHC/MPM tissues Penno et al. 1995 [79]
High CD44 level differentiates MPM from ADC IHC/reactive mesothelium, MPM, ADC samples Attanoos et al. 1997 [80]
CD44/HA localization discriminates MPM from ADC IHC/paraffin-embedded serous fluids Afify et al. 2005 [81]
CD44v6/CD44s ratio aids in differential diagnosis between MPM and non-MPM tumors ELISA/Pleural fluids Porcel et al. 2011 [84]
Low CD44 level aids in differential diagnosis of pleural neoplastic differentiation IHC/epitheloid MPM and reactive mesothelial hyperplasia tissues Ali et al. 2013 [82]
Low CD44 positivity and high HA staining may differentiate MPM from ADC IHC/MPM tissues Törronen et al. 2016 [83]
  1. MPM malignant pleural mesothelioma, ADC adenocarcinoma, HA hyaluronic acid, IHC immunohistochemistry, ELISA enzyme-linked immunosorbent assay