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Fig. 2 | Respiratory Research

Fig. 2

From: ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling

Fig. 2

Wnt dependent differential regulation of drug transporters. Relative mRNA expression of a) ABCB1 and ABCG2 expression in 3D HMVEC-L-NHLF-SAEC aggregates treated with canonical Wnt pathway inhibitor, IWR and inducer, LiCl for 3 h. mRNA of treated samples is compared to untreated controls, n = 3 b) ABCB1 and ABCG2 expression in 3D HMVEC-L-NHLF-SAEC co-culture aggregates following recombinant human Wnt5a treatment shows similar pattern that SCC primary samples. mRNA expression of treated samples is compared to untreated controls, n = 3, mRNA expression of primary SCC samples is compared to normal lung tissue

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Respiratory Research

ISSN: 1465-993X

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