Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers

Respiratory Research

Table 4 Association of CD14 Polymorphisms and Haplotypes with FEV₁ & FEV₁/FVC

CD14 Genotype	n	FEV₁ (% Predicted) Mean ± SD	p	^ap_adj	% FEV₁/FVC Mean ± SD	p	^ap_adj
rs2569193 CD14/-2838
AA	35	78.3 ± 18.4	0.85	0.98	69.4 ± 10.3	0.97	0.64
AG	228	79.7 ± 21.5			69.5 ± 12.3
GG	316	80.3 ± 21.4			69.7 ± 11.4
rs2915863 CD14/-1720
CC	90	80.7 ± 21.7	0.73	0.65	70.3 ± 10.0	0.20	0.13
CT	293	80.3 ± 20.7			69.8 ± 11.8
TT	180	78.9 ± 21.9			68.6 ± 12.2
rs5744455 CD14/-651
TT	33	85.3 ± 19.5	0.12	0.071	72.9 ± 8.3	0.14	0.12
TC	193	77.8 ± 21.4			68.6 ± 12.5
CC	339	80.4 ± 21.3			69.7 ± 11.6
rs2569190 CD14/-260
AA	134	79.7 ± 21.2	0.71	0.97	70.1 ± 11.4	0.48	0.43
GA	287	79.2 ± 21.7			69.1 ± 12.2
GG	141	81.0 ± 20.2			70.4 ± 11.0
Haplotype^b
GCCA	245^c	81.2 ± 1.7	Ref.^d	Ref.	71.0 ± 1.0	Ref.	Ref
ATCG	149	79.9 ± 1.3	0.41	0.62	70.1 ± 0.7	0.28	0.20
GTTG	134	80.7 ± 1.4	0.76	0.37	70.6 ± 0.7	0.61	0.38
GTCA	44	76.4 ± 2.3	0.056	0.25	66.4 ± 1.3	0.001	0.021
Other	12	90.5 ± 3.7	0.014	0.035	71.3 ± 2.1	0.89	0.81

Abbreviations and Definitions: FEV ₁ forced expiratory volume in 1 s, % FEV₁/FVC FEV₁/FVC x 100; FVC, forced vital capacity
^aMultivariable results (p_adj) are adjusted for age, BMI, education, sex, COPD status, race and years worked on a farm
^bHaplotypes defined as -2838/-1720/-651/-260; Mean ± SE
^cSample sizes estimated from haplotype frequency. Mean ± SE are shown
^dPairwise comparison to the Base haplotype

ISSN: 1465-993X