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Fig. 5 | Respiratory Research

Fig. 5

From: Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation

Fig. 5

Decreased protein synthesis signaling in response to pulmonary inflammation. Mice were intratracheally instilled with elastase and LPS or respective vc. Protein levels of (b) phosphorylated p70S6 (Thr389), (c) total p70S6, (f) phosphorylated S6 (ser235/236), (g) total S6, phosphorylated 4EBP1 (j) ser65 and (l) Thr37/46 and (h) total 4EBP1 were assessed in lysates of gastrocnemius muscle tissue with western blot analysis. (d) Representative western blots of indicated proteins. Ratio of (a) phosphorylated p70S6 over total p70S6, (e) phosphorylated S6 over total S6, (i) phosphorylated 4EBP1 (ser65) and (k) phosphorylated 4EBP1 (Thr37/46) over total 4EBP1. n = 8–12 per group. * p < 0.05, ** p < 0.01, *** p < 0.001, # represents a trend

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Respiratory Research

ISSN: 1465-993X

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