Fig. 2

Pulmonary inflammation causes muscle atrophy in control and emphysematous mice. Mice were intratracheally instilled with elastase to induce emphysema or vc, followed by a single bolus of LPS or vc. a 48 h after LPS, mice were sacrificed and skeletal muscle wet weights were measured and corrected for tibia length. b 48 h after LPS or vc, μCT scans were made and muscle mass was determined. c Correlation between μCT-derived muscle mass and combined muscle wet weights. * p < 0.05, ** p < 0.01, *** p < 0.001. n = 11–23 per group