2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls

Table 2 Proteins differentially expressed between COPD_Lvs COPD_Nand COPD_Lvs C groups

				COPD_Lvs COPD_N		COPD_Lvs C
Assigned spot number		Protein name	Protein symbol	P value	Av. Ratio	P value	Av. Ratio	Protein relevant function
17		Serum albumin	ALBU	0.0053	1.67	0.022	1.36	Transportation of substances in the blood.
67	Up regulated	Heat shock protein beta-1	HSPB1	0.011	1.3	6.7E-05	1.48	Heat shock, ROS scavenger
75		Alpha-crystallin B chain	CRYAB	0.017	1.38	0.00026	1.53	Heat shock, muscle homeostasis
1		Histone-lysine N-methyltransferase, H3 lysine-79 specific	DOT1L	0.0065	−2.25	0.014	−1.45	DNA repair, deficiency leads to cell arrest
91	Down regulated	Myosin light chain 1/3, skeletal muscle isoform	MYL1	0.049	−2.13	0.0048	−2.38	Myosin light chain expressed in Type II fibres, muscle cell proliferation
48		Troponin T, slow skeletal muscle	TNNT1	0.025	−2.6	0.023	−2.21	Component of the thin filament of the sarcomere
60		Myozenin-1 OS = Homo sapiens	MYOZ1	0.00086	−2.44	0.029	−1.63	Promote type II fibres, calcineurin-interacting proteins

Seven proteins were identified that full fill the criteria set for the analysis. Student t test was used to compare between different groups, p-value <0.05 significant (bold). Av. Ratio: Average. Ratio; fold change a positive value means increased ratio, a negative value means decreased ratio

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