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Table 1 Characteristics of the study groups

From: 2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls

 

Controls

COPDN

COPDL

p-value

M/F

8/1

A

6/2

A

8/2

A

ns

Age (Years)

68.8 ± 4.4

A

68.6 ± 5.2

A

66.7 ± 5.9

A

ns

Height (m)

1.74 ± 0.08

A

1.70 ± 0.09

A

1.67 ± 0.08

A

ns

Weight (Kg)

89.93 ± 15.63

A

76.1 ± 12.65

A

51.71 ± 5.71

B

<0.001

BMI (Kg.m−2)

29.3 ± 4.6

A

26.2 ± 2.4

A

18.9 ± 1.9

B

<0.0001

FFM

62.55 ± 11.35

A

54.13 ± 10.13

AB

43 ± 5.69

C

<0.001

FFMI (Kg.m−2)

20.5 ± 2.3

A

18.6 ± 1.6

B

15.3 ± 0.7

C

<0.0001

Active/ex-smokers

1/8

A

2/6

A

2/8

A

ns

Pack/Year

30.9 ± 15

A

50.9 ± 23.1

A

64.3 ± 39.8

A

ns

Average cessation (years)

24.6 ± 16.8

A

7.9 ± 7.6

B

5.4 ± 7.4

B

<0.05

Age at smoking cessation (years)

44.2 ± 15.3

A

60.8 ± 8.3

B

61.3 ± 7.8

B

0.0039

mMRC

  

2.1 ± 1.4

 

3.1 ± 1.1

 

ns

FEV1 (L)

2.9 ± 0.5

A

1.2 ± 0.5

B

0.9 ± 0.4

B

<0.0001

FEV1 (% pred)

98.6 ± 12.1

A

44.3 ± 19.9

B

33.2 ± 13.7

B

<0.0001

FVC (L)

4 ± 0.7

A

2.9 ± 1.1

B

2.6 ± 1

B

<0.01

FVC (% pred)

105.8 ± 12.4

A

85.6 ± 31.5

AB

76.5 ± 18.2

B

<0.05

FEV1/FVC

0.7 ± 0

A

0.4 ± 0.1

B

0.3 ± 0.1

B

<0.0001

PaO2 (mmHg)

74.3 ± 8

A

68.5 ± 9.7

A

75.2 ± 13.1

A

ns

PaCO2 (mmHg)

41.2 ± 2.4

A

41 ± 3.9

A

43.1 ± 5.2

A

ns

Physical Activity (V)

11.9 ± 5.1

A

6.3 ± 6

AB

1.1 ± 1

B

<0.0005

Physical Activity (L)

  

33.1 ± 16

A

43.5 ± 10.4

A

ns

QMVC (N)

372.3 ± 89

A

317.9 ± 89.9

A

202.2 ± 51.8

B

<0.005

6MWD (m)

569.3 ± 62.4

A

390 ± 170.2

B

327 ± 134.1

B

<0.005

Exacerbation

  

1.8 ± 1.5

A

4 ± 2.2

B

<0.05

BODE

  

4.3 ± 3

A

6.2 ± 2.3

A

ns

SGRQ Symptoms

  

62.9 ± 10.1

A

78.3 ± 15.2

B

<0.05

SGRQ Activity

  

56.9 ± 31

A

86.2 ± 13.4

B

<0.05

SGRQ Impact

  

37.8 ± 25

A

59.5 ± 20.8

A

ns

SGRQ Total

  

47.9 ± 21.8

A

70.7 ± 16.4

B

<0.005

Type I Fibre (%)

38.5 ± 11

A

26 ± 9.6

A

24.7 ± 13.5

A

ns

Type II area (μ2)

2564 ± 783.8

AB

3096 ± 893.6

A

2034 ± 498.8

B

<0.05

  1. Abbreviations: COPD N COPD patients with normal, FFMI COPDL patients with COPD with low FFMI, BMI Body mass index, FFM fat free mass, FFMI fat free mass index, MRC medical research council dyspnoea score, FEV 1 forced expiratory volume in the first second, FVC forced vital capacity, PaO 2 arterial oxygen partial pressure, PaCO 2 arterial carbon dioxide partial pressure, Physical Activity (V) Voorrips Questionnaire, Physical activity (L) London Chest Activity of Daily Living Scale, QMVC quadriceps maximal voluntary contraction, 6MWD six minute walking distance, SGRQ St. George’s Respiratory Questionnaire, ns not significant, NA not applicable. Comparisons among groups were done using ANOVA and Student-Newman-Keuls as a post-hoc test. Differences among the three different groups were stated using letters A,B and C where sharing a letter implies no differences between these groups and having a different letter implies a statistical difference in the post-hoc test
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Respiratory Research

ISSN: 1465-993X

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