Fig. 3

siRNA knockdown of DOT1L up regulates the expression of CDKN1A mRNA (a) and p21 protein level (b). Empty bars are untreated cells and solid bars are transfected cells. HSkMSC cultures derived from three different experiments on cells at passage three, Graph is presenting means ± SEM. *, p-value < 0.05 siRNA treated cells compared to controls