Table 1 Subject characteristics
From: Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients
Asthma (n = 205) | Healthy (n = 80) | P value | |
|---|---|---|---|
Subjects (n=) | 205 | 80 | |
Age (years) | 30–40–51 | 23–27–42 | <0.0001 |
Gender (M/F) | 96/112 | 30/50 | 0.09 |
Body Mass Index | 21.9–24.4–28.1 | 20.4–22.3–24.5 | <0.0001 |
Active smoking (%) | 25 (12%) | 2 (3%) | 0.007 |
Allergy (%) | 139 (76%) | 23 (35%) | <0.0001 |
Steroid-naive | 41 (20%) | NA | |
Inhaled steroids only | 142 (69%) | NA | |
Inhaled and oral steroids | 22 (11%) | NA | |
FEV1 % predicted (%) | 94.6 ± 19.0 | 108.9 ± 14.2 | <0.0001 |
FEV1/FVC (%) | 72.3 ± 11.4 | 81.7 ± 6.5 | <0.0001 |
FENO (ppb) | 13.4–22.0–38.6 | 10.3–16.2–22.9 | 0.0004 |
Sputum eosinophils (%) | 0.0–1.0–4.0 | 0.0–0.0–0.4 | <0.0001 |
Sputum neutrophils (%) | 13.0–35.0–58.8 | 13.8–25.4–41.1 | 0.02 |
Sputum total cell count (x106 cells) | 0.8–1.3–2.5 | 0.9–1.4–2.0 | 0.48 |
Asthma Control test (/25) | 17.0–20.5–23.0 | 25–25–25 | <0.0001 |