Fig. 3
From: Imatinib relaxes the pulmonary venous bed of guinea pigs
Contribution of K+-channels to imatinib-induced relaxation of GP pulmonary veins. a Effect of inhibition of KATP-channels (glibenclamide) on imatinib-induced relaxation in ET-1 (1 nM) pre-constricted PVs: (■) imatinib (n = 9); (
) glibenclamide (10 μM), imatinib (n = 8); (□) glibenclamide (10 μM) (n = 8); b Effect of inhibition of \( {\mathrm{BK}}_{\mathrm{Ca}}^{2+} \)-channels (iberiotoxin) on imatinib-induced relaxation in ET-1 (1 nM) pre-constricted PVs: (■) imatinib (n = 9); (
) iberiotoxin (100 nM), imatinib (n = 8); (□) iberiotoxin (100 nM) (n = 8); c Effect of inhibition of Kv-channels (5-aminopyridine) on imatinib-induced relaxation in ET-1 (1 nM) pre-constricted PVs: (■) imatinib (n = 9); (
) 4-AP (5 mM), imatinib (n = 10); (□) 4-AP (5 mM) (n = 10). a/c Corresponding concentrations of (■) and (
) were compared by the Mann–Whitney U test. b Asterisks indicate different EC50 values. P <0.05 are considered as significant: * p <0.05 and ** p <0.01