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Table 1 Dose-dependent effects of NEt-4IB and PSL on AHR

From: Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma

Methacholine (mg/mL)

0

1

6

12

25

PBS/OVA/Vehicle

0.93 ± 0.19

1.57 ± 0.15

2.22 ± 0.20

2.93 ± 0.3.3

3.95 ± 0.53

OVA/OVA/Vehicle

1.19 ± 0.26

2.63 ± 0.51

5.31 ± 0.52*

7.25 ± 0.45*

11.27 ± 0.87*

OVA/OVA/NEt-4IB 0.0015%

0.82 ± 0.05

2.14 ± 0.31

4.26 ± 0.59

5.81 ± 0.73

9.93 ± 1.66

OVA/OVA/NEt-4IB 0.005%

0.84 ± 0.10

1.66 ± 0.20

3.97 ± 0.44

6.07 ± 0.41

8.75 ± 0.56

OVA/OVA/NEt-4IB 0.015%

1.00 ± 0.15

2.10 ± 0.25

3.57 ± 0.52

5.28 ± 0.37**

7.14 ± 0.31**

OVA/OVA/PSL 0.005%

0.89 ± 0.06

1.52 ± 0.10

3.13 ± 0.34**

4.73 ± 0.47**

6.38 ± 0.42**

  1. The results for each group are expressed as the mean RL ± SEM (cmH2O s/ml) (n = 8–12 in each group). *Significant difference (P < 0.05) between PBS/OVA/Vehicle and OVA/OVA/Vehicle. **Significant difference (P < 0.05) between OVA/OVA/Vehicle and OVA/OVA/NEt-4IB or OVA/OVA/PSL