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Fig. 1 | Respiratory Research

Fig. 1

From: Pharmacological investigation on the anti-oxidant and anti-inflammatory activity of N-acetylcysteine in an ex vivo model of COPD exacerbation

Fig. 1

Frequency-response curves produced by EFS ranging from 1 Hz to 50 Hz in control bronchi and after overnight incubation with LPS (100 ng/ml), alone or together with GSH (100 μM) (a). Influence of increasing concentrations of NAC (b 10 nM to 10 μM; c 30 μM to 10 mM) on the desensitizing effect induced by LPS (100 ng/ml). Data are expressed as the mean ± SEM of n = 4 segmental bronchi from different subjects. # P < 0.05 vs. control bronchi: * P < 0.05 and **P < 0.01 vs. LPS-incubated bronchi (statistical significance assessed by two-way ANOVA for comparison among control, LPS, LPS + GSH and LPS + NAC treatments)

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Respiratory Research

ISSN: 1465-993X

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