End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern: an immunohistochemical analysis

Table 3 Quantification of total lymphoid cell types in controls and CF patients, corrected for area unit

Lymphoid cell and follicle quantification (expressed as cells or follicles/mm² area)
	Control subjects	CF patients	Mann-Whitney U test
CD4 T cells	3.8 (0.6–7.6)	9.0 (2.9–21.7)	0.007**
Cytotoxic T cells (CD8)	1.5 (0.2–11.4)	55.8 (23.7–71.5)	<0.0001***
B cells (CD20)	0.0 (0.0–0.9)	0.3 (0.1–0.8)	0.091
Lymphoid follicles	0.0 (0.0–0.009)	0.056 (0.022–0.082)	<0.0001***
Airway	0.0 (0.0–0.003)	0.014 (0.006–0.029)	<0.0001***
Parenchyma	0.0 (0.0–0.003)	0.011 (0.006–0.039)	<0.0001***
Perivascular	0.0 (0.0–0.003)	0.011 (0.004–0.023)	0.0002***

During follicle quantification, localization was taken into consideration. The p-values in the right-hand column are the result of Mann-Whitney U testing. Significant differences between CF patients and control subjects are indicated with *, with * = p < 0.05, ** = p < 0.01 and *** = p < 0.001
data < 0.05 are captured in bold

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