Table 2 Quantification of myeloid cell types in controls and CF overall and for the three compartments

Neutrophils (MPO)

17.4 (7.1–30.5)

33.7 (25.4–47.8)

0.0024**

  Airway

15.1 (6.3–28.7)

67.5 (43.5–81.9)

<0.0001***

  Parenchyma

19.7 (7.1–40.6)

28.9 (15.3–36.6)

0.18

  Perivascular

9.7 (3.5–19.4)

15.2 (9.2–18.9)

0.18

Eosinophils (EG-2)

1.0 (0.4–2.9)

2.3 (0.3–5.0)

0.82

  Airway

1.7 (0.6–5.5)

2.0 (0.5–7.7)

0.10

  Parenchyma

1.1 (0.3–2.7)

1.1 (0.1–3.6)

0.63

  Perivascular

0.6 (0.1–1.7)

0.4 (0.0–2.0)

0.61

Mast cell (tryptase)

10.5 (8.8–14.4)

17.6 (12.5–24.7)

0.018*

  Airway

18.8 (15.3–31.2)

25.2 (19.9–36.6)

0.21

  Parenchyma

7.8 (5.0–9.2)

15.0 (8.8–21.3)

0.0024**

  Perivascular

9.3 (6.9–11.1)

12.5 (9.9–15.8)

0.0082**

Dendritic cells (CD1a)

0.8 (0.4–1.5)

3.0 (2.1–4.2)

<0.0001***

  Airway

2.3 (0.8–3.6)

4.7 (3.0–6.3)

0.0013**

  Parenchyma

0.2 (0.0–0.5)

2.2 (1.0–3.8)

<0.0001***

  Perivascular

0.7 (0.1–2.0)

1.6 (0.9–3.5)

0.012*

Dendritic cells (CD207)

1.0 (0.3–1.8)

4.6 (3.7–7.6)

<0.0001***

  Airway

3.0 (1.6–4.7)

9.6 (7.6–13.2)

<0.0001***

  Parenchyma

0.0 (0.0–0.2)

2.7 (1.1–5.9)

<0.0001***

  Perivascular

0.1 (0.0–0.4)

1.2 (0.5–4.0)

0.0001***

Macrophages (CD163)

18.7 (10.3–25.1)

32.0 (23.0–39.8)

0.0021**

  Airway

15.5 (8.7–26.6)

33.8 (18.4–40.4)

0.0049**

  Parenchyma

21.3 (10.6–26.8)

35.0 (21.9–46.8)

0.011*

  Perivascular

16.9 (11.0–21.0)

22.4 (14.1–31.6)

0.064